Frequently Asked Questions
- What is CosaminDS?
- What is glucosamine?
- What is chondroitin sulphate?
- Why is it important to use glucosamine & chondroitin sulphate together?
- Is CosaminDS safe?
Download the "Frequently Asked Questions" Brochure in pdf format.
What is CosaminDS?
CosaminDS is a dual patented formulation combining precise amounts of highly purified glucosamine hydrochloride (500mg), chondroitin sulphate (400mg), and manganese gluconate (45.5mg) in each capsule. Nutramax Laboratories discovered the synergistic effect of the combination of these compounds on cartilage matrix enhancement. The recent surge of interest in cartilage-modifying agents has led to many brands of chondroitin sulphate and glucosamine being available in health food stores and other retail outlets, but CosaminDS is unique for several reasons.
Firstly, CosaminDS is made from a unique, formula that combines glucosamine, chondroitin sulphate, and manganese. Taken together, the synergistic combination of glucosamine and chondroitin sulphate with manganese as a co-factor is more beneficial than taking glucosamine or chondroitin alone base on their different mechanisms of action.
Secondly, the ingredients of CosaminDS are of unparalleled purity and uniformity and are manufactured and combined according to Good Manufacturing Practices (GMP) standards similar to those used in the pharmaceutical industry. CosaminDS combines the safety of a nutritional supplement with the purity and uniformity of a pharmaceutical grade medication, and CosaminDS is manufactured in Australia.
What is glucosamine?
Glucosamine is a small molecule biochemically classed as an amino sugar. In a healthy joint, the cartilage cells normally make glucosamine out of glucose. Glucosamine then, in turn, forms the basic building block of larger molecules in the joint tissues. Joint problems may begin when cartilage cells are not making enough glucosamine to keep up with the level of tissue destruction. Supplying the body with extra glucosamine obviously makes sense. In addition to its structural role, glucosamine directly stimulates cartilage cells, and increases their synthesis of the molecules in the cartilage matrix including hyaluronic acid which is important for synovial fluid to have its lubricating effect. Supplying extra glucosamine to the body thus maximises the production of collagen and GAGs in articular cartilage.
What is chondroitin sulphate?
Chondroitin sulphate also occurs normally in the body, specifically, it is the most abundant GAG in the articular cartilage matrix. It is a large molecule that is made in a series of reactions by the cartilage cells. Chondroitin sulphate is important because it binds to collagen, and thus gives cartilage its tensile strength and resiliency. Lack of chondroitin sulphate contributes to joint breakdown by causing cartilage to become soft. Chondroitin sulphate is certainly an important structural part of cartilage, and it also has an important effect on cartilage metabolism, in that it inhibits degredative enzymes that break down cartilage. In other words, supplementing chondroitin sulphate helps to maintain healthy cartilage by slowing cartilage breakdown.
CosaminDS contains Low Molecular Weight (LMW) chondroitin sulfate. This is important as described in the US Physicians Desk Reference as many chondroitin sulfate products are not readily absorbed in the body.
Why is it important to use glucosamine & chondroitin sulphate together?
The glucosamine and chondroitin sulphate in CosaminDS work together in a synergistic manner to help the body renew joint cartilage. As shown in clinical trials such as the GAIT and Hommandberg studies, taking the two compounds together is more effective than taking either alone based on their different mechanisms of action. Glucosamine helps the body to rebuild cartilage, and chondroitin helps to decrease cartilage breakdown.
Is CosaminDS safe?
Yes, CosaminDS has an excellent safety record. CosaminDS has been used worldwide since 1992 with no demonstrable toxicity (LD50 > 5 grams/kg) and minimal incidence of mild, dose-dependant, reversible side effects, such as gastrointestinal gas. There are no know interactions with any drug or nutritional supplement, and no known contraindications for CosaminDS use.
For more information please download our "Frequently Asked Questions" Brochure in pdf format.