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New Study on Protecting and Reversing Damage to Joints
Sunday, 01 October 2006

New Study Shows Combination of Glucosamine and Chondroitin Sulfate Better Than Individual Ingredients in Protecting and Reversing Damage to Joint

Edgewood, MD: Nutramax Laboratories, Inc. is pleased to announce results of a study* just published in a leading peer-reviewed journal. The in vitro study provides evidence that the combination of glucosamine and chondroitin sulfate has more activity in protecting, reversing damage and promoting repair in joint cartilage than glucosamine or chondroitin sulfate alone.

While providing further clinical support for in vitro research documenting effects of chondroitin sulfate and glucosamine, this study showed for the first time that damage to cartilage could be reversed by this combination of agents. The study used specific glucosamine, FCHG49**, and low molecular weight chondroitin sulfate, TRH122**, agents found exclusively in the joint health supplement, CosaminDS, marketed by Nutramax Laboratories, Inc.

In the study, led by G.A. Homandberg, Ph.D. of the University of North Dakota School of Medicine and Health Sciences, fibronectin fragments were added to cartilage sections to cause a loss of proteoglycans, which are contained within cartilage. Fibronectin fragments are compounds generated during the cycle of cartilage breakdown. Once generated, they then lead to further breakdown of cartilage and inhibit cartilage proteoglycan production with their effects on other mediators involved in the process. Physiological levels of glucosamine hydrochloride and chondroitin sulfate, alone and in combination, were added either before or after the fibronectin fragments to measure their effects. The researchers concluded that these agents had a synergistic, or better than additive, effect and that the combination worked to protect the cartilage.

The research delineated above was supported by Nutramax Laboratories, Inc.

* Homandberg GA, Guo D, Ray LM, et al. Mixtures of glucosamine and chondroitin sulfate reverse fibronectin fragment mediated damage to cartilage more effectively than either agent alone. Osteoarthritis and Cartilage 2006;14:793-806.

** CosaminDS contains FCHG49 Glucosamine Hydrochloride and TRH122 Sodium Chondroitin Sulfate, Nutramax Laboratories exclusive researched specifications