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Product Quality Studies


Adebowale A, Cox D, Liang Z, Eddington N.
Analysis of glucosamine and Chondroitin Sulphate Content in Marketed product and the Caco-2 Permeability of Chondroitin Sulphate Raw Materials.
JANA 3(1):37-44, Spring, 2000.

Original research article reports the findings of content analysis of glucosamine and chondroitin sulphate marketed products. Eighty-four percent of tested products did not meet label claim with contents ranging from 0% to 115% of the label claim. It was also shown using an absorption model that some grades of chondroitin sulphate are not absorbed whereas the low molecular weight form (Bioberica 95%+) exclusive to CosaminDS had the best absorption profile.

Correlation between price and label claims

Way W, Gibson K, Breite A
Determination of Glucosamine in Nutritional Supplements by Reversed-Phase Ion-Pairing HPLC.
J. Liq. Chrom. & Rel. Technol., 23(18): 2861-2871,2000.

Way W, Gibson K, Breite A
Determination of Chondroitin Sulphate in Nutritional Supplements By Liquid Chromatography.
J. Liq. Chrom. & Rel. Technol., 23(18): 2851-2860,2000.

Liang Z, Leslie J, Adebowale A, Ashraf M, Eddington N
Determination of the Nutraceutical Glucosamine Hydrochloride in Raw Materials, Dosage Forms and Plasma using Pre-Column Derivatisation with Ultraviolet HPLC.
J. Pharm. Biomed. Anal., 20, 807-814, 1999.

Adebowale A, Liang Z, Eddington N: Nutraceuticals, a Call for Quality Control of Delivery Systems: A Case Study with Chondroitin Sulphate and Glucosamine. J. of Nutraceuticals, Functional & Medical Foods, 2:(2):15-29, 1999.

Adebowale A, Liang Z, Eddington N
Development and Validation of a High Performance Size Exclusion Chromatographic Method for the Quantification of Chondroitin Sulphate in Raw Materials, Powder Blends, and Dosage Forms.
Accepted for publication in the Journal of Pharmaceutical and Biomedical Analysis.


McAlindon T, LaValley M, Gulin F, Felson D
Glucosamine and Chondroitin for Treatment of Osteoarthritis
JAMA 283:11 1469-1475, March 15, 2000. **

Meta-analysis of European glucosamine and chondroitin sulphate trials reported chondroitin to have a greater effect than glucosamine. The authors concluded that there appears to be efficacy for these supplements

** The chondroitin sulphate evaluated in this paper is the identical low molecular weight chondroitin sulphate contained in CosaminDS


Davis WM
The role of glucosamine and chondroitin sulphate in the management of arthritis
Drug Topics (Supplement):3S-13S, April 1998.

Hungerford DS
Treating osteoarthritis with chondroprotective agents
Orthopaedic Special Edition 4(1):39-42, 1998.

Das A
The biochemistry of cartilage and osteoarthritis treatment options. A CME accredited special report.
New York, McMahon Publishing Group, pp 1-4, January 1999.

Schenck RC
Osteoarthritis treatment and potential structure modification with nutraceuticals. A CME Accredited Special Report
New York, McMahon Publishing Group, pp 1-4, August 1999.

Hungerford D, Navarro R, Hammad T
Use of nutraceuticals in the management of osteoarthritis
Journal of the American Nutraceutical Association 3(1):23-27, 2000.